Premature Ovarian Insufficiency (POI) is a multi-factorial disorder that affects women of reproductive age.The condition is characterized by the loss of ovarian function before the age of 40 years and several factors have been identified to be implicated in BLADDER ONE FOR WOMEN its pathogenesis.Remarkably though, at least 50% of women have remaini
Genome-Wide Scan for Runs of Homozygosity Identifies Candidate Genes Related to Economically Important Traits in Chinese Merino
In this study, we estimated the number, length, and frequency of runs of homozygosity (ROH) in 635 Chinese Merino and identified genomic regions with high ROH frequency using the OvineSNP50 whole-genome genotyping array.A total of 6039 ROH exceeding 1 Mb were detected in 634 animals.The average number bowls of ROH in each animal was 9.23 and the av
Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques
Abstract Background Mucosally transmissible and pathogenic CCR5 (R5)-tropic simian-human immunodeficiency virus (SHIV) molecular clones are useful reagents to identity neutralization escape in HIV-1 vaccine experiments and to study the envelope evolutionary process and mechanistic basis for coreceptor switch during the course of natural infection.R